Disease Description
“Tourette syndrome is a rare disorder that causes people to make unusual movements or sounds, called “tics.” Common examples of tics include blinking and throat clearing. People with the disorder have little or no control over their tics. Many people with Tourette syndrome have mild symptoms, but some have more severe ones. Most people with Tourette syndrome start showing signs of the disorder before they are 11 years old. In about half of children with Tourette syndrome, the tics go away by the time they turn 18. Tics that continue into adulthood gradually improve over time in many people. But in some people, the tics return later in life.” - Uptodate.com
Prevalence
“In a meta-analysis of 13 studies that specifically assessed TS in children, the prevalence of TS was 7.7 per 1000 children (95% CI 3.9-1.51) [18]. The prevalence was higher in boys compared with girls (10.6 versus 2.5 per 1000).” - Uptodate.com
Current Treatment Options
“Children and adults with Tourette syndrome don’t need medical treatment unless their tics are severe. A person with Tourette syndrome might need treatment if he or she is having problems:
●Talking with other people
●Attending school or working at a job
●Doing everyday things such as bathing, dressing, and eating Treatments include:
●Medicines – Certain medicines used to treat different mental health conditions can lower the number of tics a person has.
●Botulinum toxin (brand name: Botox) – This is a medicine that is given by injection. It works by blocking or calming the nerve signals that make the muscles jerk or twitch.
●Habit reversal training – This treatment involves working with a therapist who teaches people with Tourette syndrome to recognize when they are about to have a tic. Then, the people train themselves to do a different movement that makes it hard to do the tic. This treatment is not available everywhere.” -uptodate.com
Evidence for and Proposed Mechanism for Cannabinoids Therapeutics
"Anecdotal reports have suggested beneficial effects of marijuana (Cannabis sativa) in TS. Sandyk and Awerbuch (2) reported that three TSpatients experienced a significant amelioration of symptoms when using marijuana. These 15- to 39- year-old male patients had noted an improvement of tic severity, urge to tic, self-mutilatory behaviour, attention span, hypersexuality and a generalized relaxation when they smoked half to two marijuana cigarettes per day. Hemming and Yellowlees (3) described a single case of a 36- year-old man who had reported that he had been symptom free for more than 1 year while he was taking one 'cone' of marijuana per night.
Retrospective chart review. Our results provide more evidence that marijuana improves tics and behavioural disorders in TS. It can be speculated that cannabinoids might act through specific receptors, and that the cannabinoid system might play a major role in TS pathology." -Emrich HM, et al. Treatment of Tourette’s Syndrome with Δ9-Tetrahydrocannabinol (THC): A Randomized Crossover Trial. Pharmacopsychiatry 2002; 35: 57-61
In Germany, a study conducted at the Medical School Hannover stated:
"Previous studies provide evidence that marijuana (Cannabis sativa) and Δ9-tetrahydrocannabinol (Δ9-THC), the major psychoactive ingredient of marijuana, respectively, are effective in the treatment of tics and behavioral problems in Tourette syndrome (TS). It, therefore, has been speculated that the central cannabinoid receptor system might be involved in TS pathology. However, in healthy marijuana users there is an ongoing debate as to whether the use of cannabis causes acute and/or long-term cognitive deficits. In this randomized double-blind placebo-controlled study, we investigated the effect of a treatment with up to 10 mg Δ9-THC over a 6-week period on neuropsychological performance in 24 patients suffering from TS. During medication and immediately as well as 5-6 weeks after withdrawal of Δ9-THC treatment, no detrimental effect was seen on learning curve, interference, recall and recognition of word lists, immediate visual memory span, and divided attention. Measuring immediate verbal memory span, we even found a trend towards a significant improvement during and after treatment. Results from this study corroborate previous data suggesting that in patients suffering from TS, treatment with Δ9-THC causes neither acute nor long-term cognitive deficits. Larger and longer-duration controlled studies are recommended to provide more information on the adverse effect profile of THC in patients suffering from TS."
Recent GBXI News:
May 11, 2023, GBX International Group, Inc., (OTC: GBXI)
GBX International Group, Inc. (OTC:GBXI) Confirms 2023 Strong Revenue Growth Guidance Projections by Combining Each Acquired Operating Company Product Release, Expects Strong Growth Sector by Sector Through its Multiple Product Releases into North American and International Markets
April 21, 2023, GBX International Group, Inc., (OTC: GBXI)
HARVARD Award Winning Entrepreneur, Mr. Raymond C. Dabney Acquires Majority Shareholder Control of GBX International Group, Inc. (OTC: GBXI) Makes More History Bringing CSi-EDP Partner American States University (ASU) as the First Acquisition for its Aggressive Growth Plans
The ASU Digital Business HUB will be used as the main business student learning center. GBXI will be the main pivot point to spin out trading shares of all our Partner Public and Private Companies such as Cannabis Science, iCannabinoid, Thermic Science, LNC, LMG, and a few more old and new school surprises for our loyal shareholders. No one will be missed! A true Digital Business HUB for students, just as planned all along.
Each spinout company will give our GBXI registered shareholders additional pro-rata shares in each spinout company over and above their original shares in each entity. This provides the required shareholder base for each company required to trade and gives additional shares to all our loyal GBXI shareholders.
We call this “Compounding our Wealth” through extra spinout share participation for all our loyal GBXI shareholders. Each registered GBXI shareholder will receive additional shares of each spinout Company over and above their original shares to enjoy additional liquidity as each company begins to trade through the GBXI Digital Business HUB spinout process.
Click here to review the Report:
Case No. 2:17-CV-02271-KJM-JDP
Inspire, Dream, Change
YOUR DIGITAL ERA Personal & Business Access Learning HUB
Hello Raymond,
Anything new and exciting for to report on our progress? Curious minds want to know! We should start trading soon I would hope...Hello Raymond,
Anything new and exciting for to report on our progress? Curious minds want to know! We should start trading soon I would hope. Always forward my friend
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Hi Raymond,
As a long-standing Loyal Shareholder, I hope that this posting finds you in good health and good spirits. I made my first CBIS purchase...Hi Raymond,
As a long-standing Loyal Shareholder, I hope that this posting finds you in good health and good spirits. I made my first CBIS purchase in Sept 2014 (Dr. Bob was still at CBIS) and I made my last purchase in June 2017; just prior to the Hemp Seizure that F'k-up everything for CBIS going forward.
BUT, on 2017-01-09 CBIS Entered into 1 yr. Research Collaboration Agreement (RCA) with Dana Farber Cancer Institute (DFCI) to Develop Cannabinoid-Based Medications and Associated Delivery Technologies for the Treatment of Cancers.
Then on 2018-01-18 1st Frontiers In Oncology Article: "Nano Particle Drone to Target Lung Cancer with Radio Sensitizers & Cannabis." - KILLING CANCER
And then again on 2018-02-02 CBIS expanded the RCA with DFCI for 5 yrs. (@ $1.8M) to develop Cannabinoid-Based Medications and Associated Delivery Technologies for the Treatment of Cancers. That RCA agreement expired on 2023-02-02.
NOW, On 2023-02-02 the Expanded RCA with DFCI has ended. THE RESULTS ARE NOW KNOWN:
For the $1.8mil investment with DFCI, several Cancer Killing Formulations have been developed.
#1-6 Represents the drug formulations developed by DFCI during the 5yr RCA for treatment of the following cancers:
1. Skin Cancer
2. Breast Cancer
3. Brain Cancer
4. Kaposi's Sarcoma
5. Lung Cancer
6. Pancreatic Cancer
7. CBN Patent Valuation
#7 is the US Patent that was awarded to CBIS which describes the formulation used to treat certain neurological ailments such as ODD, ADD, etc.
On 2023-05-08 it was announced that GBXI signs the first 3 acquisitions for the GBXI Conglomerate (follow link below for details)
finance.yahoo.com/news/gbxi-advances-forward-signs…
Then On 2023-12-13 you posted the following: "GBXI Corporate Filings, Financials, and trading status has been delayed due to change of control filings and approvals. The Company has several options on the list for trading resumption as it pursues its regulatory approvals. The Company is pursuing the fastest path to trading first and will proceed down the list as it moves towards its ultimate goal of bringing all the GBXI conglomerate company shares back trading again.
QUESTION: Where are we toward the completion of this process?? 50% / 75% / 90% ????
--------
Some info that the I have found about a SPAC is as follows:
When does a SPAC become public?
--------------------------------------------
These types of transactions, most commonly where a SPAC acquires or merges with a private company, occur after, often many months or more than a year after, the SPAC has completed its own IPO. Unlike an operating company that becomes public through a traditional IPO, however, a SPAC is a shell company when it becomes public.
Period to consummate the initial business combination.
--------------------------------------------------------------------
A SPAC will typically provide for a two-year period to identify and complete an initial business combination transaction. However, some SPACs have opted for shorter periods, such as 18 months. The SPAC’s governing instruments may permit it to extend that time period. If a SPAC seeks to extend the time period, it may be required to seek shareholder approval. If a SPAC lists its securities on an exchange, it is required to complete an initial business combination within three years of its IPO. IPO proceeds are held in the trust account until a SPAC consummates a business combination or liquidates. If the SPAC is liquidated, shareholders at the time of the liquidation will be entitled to their pro rata share of the aggregate amount then on deposit in the trust account.
On 2023-11-08 an independent entity named Capizate, Inc.; prepared and presented a "Situation Analysis of the GBX International Group" which provided a list of Strengths, Areas of Improvements, and a Cancer Drug Valuation of just one of the drug formulations noted above ($25Mil-$29Mil) - Impressive.
However, here is the list that I have concern for; can't go PUBLIC without being fixed:
Areas for improvement
----------------------------
1. The business documents, agreements, term sheets, engagements are all dated in 2017-2018 and need to be updated.
2. Ownership and control of the intellectual property needs to be defined and confirmed.
3. A similar entity has active registration with California Secretary of State. The Company has a different address than on the Company website and also had a Statement of Info due to the California Secretary of State on 05/10/2023. Registered with the California Secretary of State as a Non-Profit Nonprofit Corporation - CA - Mutual Benefit. This will need to be defined.
QUESTIONS:
---------------
(1) Who's working on updating documentation? What's the % complete?
(2) Who owns and/or controls the CBIS Intellectual Property?
(3) is there another entity out there using the same name as Cannabis Science?
(4) WHERE IS BRINGING CBIS BACK PUBLIC AGAIN ON YOUR LIST OF PRIORITIES?
Thank you Raymond in advance of your response.
Best Regards
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Cannabis Science CEO, Presents …
The FINAL “CBIS GIFT Shares” Issuances!
DECEMBER 1, 2022, Cheers! & HAPPY HOLIDAYS !!!
ALL GIFT Shares 1, 2, & 3 being ISSUED !!!
LAST Steps:
Please confirm Yours NOW !!!
1. CONFIRM Correct Total Share Amount(s)
2. CONFIRM Correct Name(s) on CERTIFICATE
3. CONFIRM Correct Mailing Address
ASU/CSi-EDP-ECO-System
At it's FINEST !!!
WHICH ONE ARE YOU ??
Those who, MAKE things happen.
Those who WATCH things happen.
Those who WONDER what the ... HAPPENED ???
We can make this HAPPEN way FASTER Working as a TEAM !!!
WHAT Matters is how much you CARE about KILLING CANCERS ...
This is it ... We are ALL Here ... Now ... with a Bunch of Celebrities going on TV Worldwide to Start raising $20 Million to Keep Killing Cancers.
2023 Audit considerations NASDAQ.
Cannabis Science Inc.
Share Structure 2023
Par Value: $0.001 USD
Last Price: $0.00647 USD
OTC Markets.
Common Stock:
Authorized:
5,000,000,000
Issued:
2,521,095,296
Class A Common Stock
Authorized:
100,000,000
Issued:
0
Class B Common Stock
Authorized:
1,500,000,000
Issued:
0
Preferred Stock
Authorized:
1,000,000
Issued:
1,000,000
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