BASAL CELL CARCINOMA

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Disease Description
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Basal cell carcinoma's (BCC) are abnormal, uncontrolled growths or lesions that arise in the skin’s basal cells. Basal cells are cells which line the outermost layer of the skin. BCCs often have the appearance of open sores, red patches, pink growths, shiny bumps, or scars. They are usually caused by a combination of cumulative UV light exposure and intense, occasional UV light exposure. BCC’s can be highly disfiguring if allowed to grow, but almost never spreads (metastasizes) beyond the original tumor site to become a life threatening disease. [1]

Prevalence

Estimates of the incidence of BCC are imprecise since there is no cancer registry that collects data on BCC. The American Cancer society estimates that more than two million nonmelanoma skin cancers were treated in the United States in 2006, of which the majority would have been BCC [2]

Current Treatment Options

For superficial low-risk Basal Cell Carcinoma lesions treatment options include surgical excision, or topical treatment with topical 5-fluorouracil or imiquimod.[3]

Evidence for and the Proposed Mechanism for Cannabinoid Threapies

Accumulating recent evidence implicates the endocannabinoid system in the regulation of growth of skin cells. Casanova et al. have demonstrated that various human skin tumors (e.g. basal cell carcinoma, squamous cell carcinoma) express cannabinoid receptors both CB1 and CB2. Local administration of synthetic CB1 and CB2 agonists induced growth inhibition of malignant skin tumors in mice. This growth inhibition was accompanied by enhanced intra-tumor cell death and impaired tumor vascularization (altered blood vessel morphology, decreased expression of pro-angiogenic factors such as VEGF, placental growth factor and angiopoietin 2) [4]

1. Skin Cancer Foundation. www.skincancer.org/

2. American Cancer Society Cancer Facts and Figures 2010.

3. UpToDate Online resources. Uptodate.com

4. Pacher, P. et al. The endocannabinoid system of the skin in health and disease: novel perspectives and therapeutic opportunities. Trends Pharmacol Sci. Aug 2009; 30(8): 411–420.

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Critical Ailmentsslot777
Created
Thursday, 16 March 2017
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CBIS

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Activity Stream

Raymond,
Any update on when our CBIS shares can trade again?

Raymond C. Dabney Good morning Mike, Francis and EVERYONE not understanding were we are at in bringing our shares back trading on NASDAQ. I've certainly put out lots... Show more 6 days ago

•••

Good morning Mike, Francis and EVERYONE not understanding were we are at in bringing our shares back trading on NASDAQ. I've certainly put out lots of info on our progress todate through all our previous email reports we have sent out.

(Cancelled aquisitions of Cannabis Science, Share Exchanges, and FIRST RIGHTS Options for our Original CBIS-VIP's along with the rest.)

When our next Event is Completed I will put out an actual News Release outlining the Success we've had bringing ALL our shares back to trade on NASDAQ.

Perhaps you missed this last update:

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The 1-Million Strong Killing Cancers Foundation, the 1-Million... Show more

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Jon Morse, Raymond C. Dabney and 2 others

Raymond C. Dabney We are CERTAINLY LIVE !!!
We will be announcing the TV Show/Podcast, New Crypto Contests, and our up coming Events!

Cheers Guys!
May God Bless us... Show more