Disease Description
Traumatic brain injury occurs when an external mechanical force causes brain dysfunction.
Traumatic brain injury usually results from a violent blow or jolt to the head or body. An object penetrating the skull, such as a bullet or shattered piece of skull, also can cause traumatic brain injury.
Mild traumatic brain injury may cause temporary dysfunction of brain cells. More serious traumatic brain injury can result in bruising, torn tissues, bleeding and other physical damage to the brain that can result in long-term complications or death. - mayoclinic.org
Prevalence
In 2010 the US Centers for Disease Control and Prevention calculated the rate of traumatic brain injury emergency visits to be 823.7 per 100,000 visits.
Current Treatments
Mild traumatic brain injuries usually require no treatment other than rest and over-the-counter pain relievers to treat a headache. However, a person with a mild traumatic brain injury usually needs to be monitored closely at home for any persistent, worsening or new symptoms. He or she also may have follow-up doctor appointments.
Emergency care for moderate to severe traumatic brain injuries focuses on making sure the person has an adequate oxygen and blood supply, maintaining blood pressure, and preventing any further injury to the head or neck. This can be accomplished with a variety of medications (diuretics, anti-seizure drugs, coma-inducing drugs) or surgical techniques. - mayoclinic.org
Evidence for and Proposed Mechanism of Action of Cannabinoids
Animal models have shown cannabinoids to be neuroprotective after trauma, demonstrating reduced glutamate excitotoxicity, free radical damage, and inflammatory response.3, 4 Other animal studies have shown decreased vasospasm and inhibition of tumor necrosis factor-a, both of which are associated with neuroprotection.5, 6
Aditionally a 3-year retrospective review of registry data at a surgical intensive care unit of patients sustaining traumatic brain injury demostrated that a positive THC screen is associated with decreased mortality in these adult patients.
1. Yoles E, Belkin M, Schwartz M. HU-211, a nonpsychotropic cannabinoid, produces short- and long-term neuroprotection after optic nerve axotomy. J Neurotrauma 1996;13:49–57.
2. Brewter ME, Pop E, Foltz RL, et al. Clinical pharmacokinetics of escalating IV doses of dexanabinol (HU-211), a neuroprotectant agent, in normal volunteers. Int J Clin Pharmacol Ther 1997;35: 361–5.
3. Durmaz R, Ozsandik A, Sahintu¨rk V, et al. Dexanabinol prevents development of vasospasm in the rat femoral artery model. Neurosurg Rev 2008;31:215–23.
4. Brewter ME, Pop E, Foltz RL, et al. Clinical pharmacokinetics of escalating IV doses of dexanabinol (HU-211), a neuroprotectant agent, in normal volunteers. Int J Clin Pharmacol Ther 1997;35: 361–5.
5. Nguyen et al. Effect of Marijuana Use of Outcomes in TBI. Presented at the 25th Annual Scientific Meeting of the Southern California Chapter of the American College of Surgeons, January 17–19, 2014
The ASU Digital Business HUB will be used as the main business student learning center. GBXI will be the main pivot point to spin out trading shares of all our Partner Public and Private Companies such as Cannabis Science, iCannabinoid, Thermic Science, LNC, LMG, and a few more old and new school surprises for our loyal shareholders. No one will be missed! A true Digital Business HUB for students, just as planned all along.
Each spinout company will give our GBXI registered shareholders additional pro-rata shares in each spinout company over and above their original shares in each entity. This provides the required shareholder base for each company required to trade and gives additional shares to all our loyal GBXI shareholders.
We call this “Compounding our Wealth” through extra spinout share participation for all our loyal GBXI shareholders. Each registered GBXI shareholder will receive additional shares of each spinout Company over and above their original shares to enjoy additional liquidity as each company begins to trade through the GBXI Digital Business HUB spinout process.
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Can you advise us as to when the original CBIS stock will be converted and what will the new stock be listed under - its ticker symbol.
Good Afternoon, Guys! Do we EVER have an Update for you, as stated earlier, 2024 is our Year! We are in the process of closing a couple of new...Good Afternoon, Guys! Do we EVER have an Update for you, as stated earlier, 2024 is our Year! We are in the process of closing a couple of new Partnership deals for Cannabis Science and our Expedited cancer drug development program. We are still working on the paperwork, but we can certainly start Thanking God now! That is for sure! We will be putting News Releases out in each respective Public Company and continue our FDA quest for an IND# so we can start Phase 1 Clinical Studies for Killing these Nasty Cancers.
As mentioned earlier, we will shut down the CSi-VIP Legacy Drug Ownership Program as soon as we close the first deal, the paperwork is forthcoming. We are still working on the investment reports for ALL our CSi-VIPs as stated, so you still have time to purchase your personal share of the CSi-Legacy Cancer Drug! It has certainly been a long time coming!
If you are NOT a CSi-VIP and you are interested in directly owning a piece of our CSi-Legacy Drug, it’s NOT too late for you either!
The CSi-VIP Legacy Drug Ownership Program links are all Live and updated, if you have any questions, Please feel free to contact me directly for ALL your options available this week.
*** Send me an email with your questions and contact info.
raymond.dabney@cannabisscience.com
Ps … For ALL of you sending emails “feeling off” about our continuous CSi-VIP Gifts and Offerings. Maybe you will be more comfortable if we start selling some of our own Shiny Sneakers, Bibles, Bobbleheads, NFTs, Coins, Hats, Socks, Coffee Mugs, Stickers, Calendars, Inflatable Pool Toys, Trading Cards, Toilet Paper, a Hat with MY Hair, Posters, Signed Autographs, Chia Pet Head, Flags, Clocks, Pins, and I’m sure we can come up with many more creative Fun Items. So, in the near Future, we will open our own “1 Million Strong-CSi-iCannabinoid-ASU Gift Shop” for EVERYONE to take your pick of our own Branded Merchandise for your enjoyment and specialty items collection.
*** Right now, with our CSi-VIP offerings, you Only need to KNOW that ALL your funding is going towards the continuous Successful operations required to bring our “Low-Cost, CSi-Cancer Killing Drugs” to market ASAP. You are a BIG part of the Key to Make that Change. So, let’s make sure you are a CSi-Legacy Drug Owner before that door closes too, that is the Best I can say, for now.
Good Bless us ALL.
Talk soon Guys.
Raymond - IGWT
raymond.dabney@cannabisscience.com
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Cannabis Science CEO, Presents …
The FINAL “CBIS GIFT Shares” Issuances!
DECEMBER 1, 2022, Cheers! & HAPPY HOLIDAYS !!!
ALL GIFT Shares 1, 2, & 3 being ISSUED !!!
LAST Steps:
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2023 Audit considerations NASDAQ.
Cannabis Science Inc.
Share Structure 2023
Par Value: $0.001 USD
Last Price: $0.00647 USD
OTC Markets.
Common Stock:
Authorized:
5,000,000,000
Issued:
2,521,095,296
Class A Common Stock
Authorized:
100,000,000
Issued:
0
Class B Common Stock
Authorized:
1,500,000,000
Issued:
0
Preferred Stock
Authorized:
1,000,000
Issued:
1,000,000
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Hey Mike good morning! Hope all is well for you! Sorry for the delayed response I know this is your second poke! Once... Show more 1 week ago